Structural Analysis of Putative Cytochromes: Towards a Molecular Understanding of LPMO Activation
نویسنده
چکیده
منابع مشابه
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation
A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-binding cytochrome (CYT) connected via a flexible linker to a flavin-dependent d...
متن کاملUnravel endogenous redox partner for LPMO 1 Identification of an endogenous redox partner for lytic polysaccharide monooxygenase-based oxidative cleavage of polysaccharides
Lytic polysaccharide monooxygenases (LPMOs) are oxidative biocatalysts important for biofuel development. LPMOs use molecular oxygen and an external electron donor to cleave chemically recalcitrant polysaccharide. Because of LPMOs important role in carbohydrate turnover, interest in their mechanism of action and identification of their redox partners has recently surged. Current knowledge of th...
متن کاملNovel Isatin-based activator of p53 transcriptional functions in tumor cells
Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition met...
متن کاملPutative Binding Sites of Dopamine and Arachidonoyl Dopamine to Beta-lactoglobulin: A Molecular Docking and Molecular Dynamics Study
Because of participation in many aspects of human life, and due to oxidation-sensitive characteristics of dopamine (DA) and arachidonoyl dopamine (AA-DA), the necessity of biocompatible carrier to keep them against oxidation is of importance. In this work, we explored the putative binding sites of DA and AA-DA to -lactoglobulin (BLG) as potent carrier. Docking results identified the binding si...
متن کاملBoosting LPMO-driven lignocellulose degradation by polyphenol oxidase-activated lignin building blocks
BACKGROUND Many fungi boost the deconstruction of lignocellulosic plant biomass via oxidation using lytic polysaccharide monooxygenases (LPMOs). The application of LPMOs is expected to contribute to ecologically friendly conversion of biomass into fuels and chemicals. Moreover, applications of LPMO-modified cellulose-based products may be envisaged within the food or material industry. RESULT...
متن کامل